ATF2 Rabbit Polyclonal Antibody

CAT#: TA327301

ATF2 Rabbit Polyclonal Antibody


USD 380.00

3 Weeks*

Size
    • 100 ul

Frequently bought together (1)
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    • 30 ul

USD 159.00

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 1:500 - 1:2000;IHC 1:50 - 1:200
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human ATF2
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 56 kDa
Gene Name activating transcription factor 2
Background The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins . ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways . Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71 . Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 . In addition, mutations at these sites reduce the ability of E1A and Rb to stimulate gene expression via ATF-2 .
Synonyms CRE-BP1; CREB-2; CREB2; HB16; TREB7
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways MAPK signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.