HCLS1 Rabbit Polyclonal Antibody

CAT#: TA327309

HCLS1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of HEK-293 cell lines, using HCLS1 antibody.

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  Immunohistochemical of paraffin-embedded human kidney cancer using HCLS1 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemical of paraffin-embedded human rectal cancer using HCLS1 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HCLS1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hematopoietic cell-specific Lyn substrate 1
• Database Link:
  NP_005326
  Entrez Gene 15163 MouseEntrez Gene 3059 Human
  UniProt ID P14317
• Background: HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse. Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLC?1. HS1 also plays an important role in platelet activation.
• Synonyms: CTTNL; HS1; lckBP1; p75

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Pathogenic Escherichia coli infection, Tight junction