IL1 alpha (IL1A) Rabbit Polyclonal Antibody

CAT#: TA327311

IL1A Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using IL1A antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human IL1A
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 1 alpha
• Database Link:
  NP_000566
  Entrez Gene 3552 Human
  UniProt ID P01583
• Background: IL-1a is a pro-inflammatory cytokine produced by activated monocytes, lymphocytes and epithelial cells. IL-1a is synthesized as an active precursor protein that appears to be cleaved by cytosolic proteases into its mature form . Often, precursor and mature forms of IL-1a are primarily retained intracellularly rather than constitutively secreted. . Signaling by IL-1a involves IL-1a binding to an IL-1 accessory protein (IL-1-AcP) and then the complex binds to IL-1RI . Signaling is through activation of MAP kinase and NF?B pathways . IL-1a also binds to an IL-RII that lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. Inhibition of IL-1a activity is through IL-1R antagonist (IL-1Ra) that binds IL-1R1 but does not signal. IL-1a has been shown to be a key mediator of virus-induced inflammatory responses in mice .
• Synonyms: IL-1A; IL1; IL1-ALPHA; IL1F1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, Prion diseases, Type I diabetes mellitus