PMS1 Rabbit Polyclonal Antibody

CAT#: TA327321

PMS1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PMS1 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PMS1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 106 kDa
• Gene Name: PMS1 homolog 1, mismatch repair system component
• Database Link:
  NP_000525
  Entrez Gene 5378 Human
  UniProt ID P54277
• Background: PMS1 belongs to the DNA mismatch repair mutL/hexB family. It is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in PMS1 cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other proteins involved in the HNPCC phenotype, which is also known as Lynch syndrome.
• Synonyms: HNPCC3; hPMS1; MLH2; PMSL1

Reference Data

• Protein Families: Druggable Genome, Transcription Factors