Epac1 (RAPGEF3) Rabbit Polyclonal Antibody

CAT#: TA327333

Rabbit anti-RAPGEF3 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using RAPGEF3 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human RAPGEF3
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Rap guanine nucleotide exchange factor 3
• Database Link:
  NP_006096
  Entrez Gene 223864 MouseEntrez Gene 10411 Human
  UniProt ID O95398
• Background: EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation, exocytosis, insulin signaling, axon growth and guidance and neurotransmitter release.
• Synonyms: bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275

Reference Data

• Protein Pathways: Leukocyte transendothelial migration, Long-term potentiation