UHRF1 Rabbit Polyclonal Antibody

CAT#: TA327338

UHRF1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using UHRF1 antibody.

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  Immunofluorescence analysis of U20S cell using UHRF1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ELISA, ICC/IF, IHC, WB
• Recommended Dilution: WB,1:100 - 1:500
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90kDa
• Gene Name: ubiquitin like with PHD and ring finger domains 1
• Database Link:
  NP_037414
  Entrez Gene 18140 MouseEntrez Gene 29128 Human
  UniProt ID Q96T88
• Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
• Synonyms: hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106

Reference Data

• Protein Families: Druggable Genome, Transcription Factors