UHRF1 Rabbit Polyclonal Antibody

CAT#: TA327338

UHRF1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using UHRF1 antibody.

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  Immunofluorescence analysis of U20S cell using UHRF1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:20- 1:50
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human UHRF1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ubiquitin like with PHD and ring finger domains 1
• Database Link:
  NP_037414
  Entrez Gene 18140 MouseEntrez Gene 29128 Human
  UniProt ID Q96T88
• Background: UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5-CCAAT-3 box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.
• Synonyms: hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106

Reference Data

• Protein Families: Druggable Genome, Transcription Factors