FOXM1 Rabbit Polyclonal Antibody

CAT#: TA327372

FOXM1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using FOXM1 antibody.

Specifications

Product Data

• Applications: ChIP, WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human FOXM1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: forkhead box M1
• Database Link:
  NP_068772
  Entrez Gene 14235 MouseEntrez Gene 58921 RatEntrez Gene 2305 Human
  UniProt ID Q08050
• Background: Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis and cell proliferation. FoxM1 expression increases during G1 and S and reaches maximum levels in G2/M. Nuclear translocation occurs just before entry into G2/M and is associated with FoxM1 phosphorylation. Phosphorylation of FoxM1 by MAPK (Ser331 Ser704), Cyclin/Cdk (Thr600, Thr611, Thr672), Plk1 (Ser715, Ser724), and Chk2 (Ser376) stabilizes and activates FoxM1. Forkhead box M1 is expressed in all embryonic tissues but is restricted to proliferating tissues in adults. Recent studies have shown that FoxM1 expression is negatively regulated by p53. Upregulation of FoxM1 is associated with many human cancers, including prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver, and kidney, and may be associated with p53 mutations in some tumors. As a result, FoxM1 inhibitors have become a topic of interest for potential cancer therapy.
• Synonyms: FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT

Reference Data

• Protein Families: Transcription Factors