Dopamine beta Hydroxylase (DBH) Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH)
USD 605.00
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Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB 1:500 - 1:1000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human DBH |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 69 kDa |
Gene Name | dopamine beta-hydroxylase |
Database Link | |
Background | Dopamine β-Hydroxylase (DBH) is an enzyme of the copper type II ascorbate-dependent mono-oxygenase family. This enzyme forms homotetramers composed of two noncovalently bound disulfide-linked dimers and is found as both membrane-associated and soluble forms . The soluble form is present in the lumen of secretory granules and is released from cells by exocytosis . DBH converts dopamine to noradrenaline . Deficiency in this enzyme causes a rare disease characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased plasma dopamine levels. Orthostatic hypotension, the main symptom of DBH deficiency, can be alleviated by administration of dihydroxyphenylserine, a synthetic precursor of noradrenaline . |
Synonyms | DBM |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Metabolic pathways, Tyrosine metabolism |
Documents
Product Manuals |
FAQs |
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