Gelsolin (GSN) Rabbit Polyclonal Antibody

CAT#: TA327454

GSN Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of RAW264.7 cell lysate, using GSN antibody.

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  Immunohistochemistry of paraffin-embedded human ovarian cancer tissue using GSN antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human GSN
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90 kDa
• Gene Name: gelsolin
• Database Link:
  NP_000168
  Entrez Gene 227753 MouseEntrez Gene 2934 Human
  UniProt ID P06396
• Background: The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
• Synonyms: ADF; AGEL

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton