KCNH2 Rabbit Polyclonal Antibody

CAT#: TA327461

Rabbit anti-KCNH2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using KCNH2 antibody.

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  Immunohistochemistry of paraffin-embedded rat heart using KCNH2 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human KCNH2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90 kDa
• Gene Name: potassium voltage-gated channel subfamily H member 2
• Database Link:
  NP_000229
  Entrez Gene 16511 MouseEntrez Gene 117018 RatEntrez Gene 3757 Human
  UniProt ID Q12809
• Background: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
• Synonyms: ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transcription Factors, Transmembrane