E Cadherin (CDH1) Rabbit Polyclonal Antibody

CAT#: TA327491

Rabbit anti-CDH1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of mouse lung, using CDH1 antibody.

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  Immunohistochemistry of paraffin-embedded human cervical cancer tissue, using CDH1 antibody.

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  Immunohistochemistry of paraffin-embedded human esophagus using CDH1 antibody at dilution of 1:200 (40x lens).

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  Immunohistochemistry of paraffin-embedded human gastric using CDH1 antibody at dilution of 1:200 (40x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human CDH1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 135 kDa
• Gene Name: cadherin 1
• Database Link:
  NP_004351
  Entrez Gene 12550 MouseEntrez Gene 83502 RatEntrez Gene 999 Human
  UniProt ID P12830
• Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
• Synonyms: Arc-1; CD324; CDHE; ECAD; LCAM; UVO

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer