Sumo 3 (SUMO3) Rabbit Polyclonal Antibody

CAT#: TA327516

Rabbit anti-SUMO3 Polyclonal Antibody

Product Images

Western blot analysis of extracts of MCF7 cell line, using SUMO3 antibody.

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  Immunohistochemistry of paraffin-embedded mouse brain using SUMO3 antibody.

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  Immunohistochemistry of paraffin-embedded rat brain using SUMO3 antibody.

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  Immunohistochemistry of paraffin-embedded human prostate using SUMO3 antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:1000 - 1:2000;IHC 1:50 - 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human SUMO3
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 12 kDa
• Gene Name: small ubiquitin-like modifier 3
• Database Link:
  NP_008867
  Entrez Gene 20610 MouseEntrez Gene 499417 RatEntrez Gene 6612 Human
  UniProt ID P55854
• Background: Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family. The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein. Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target. In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and I¦ÊB-¦Á to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.
• Synonyms: SMT3A; Smt3B; SMT3H1; SUMO-3

Reference Data

• Protein Families: Druggable Genome