c Kit (KIT) Rabbit Monoclonal Antibody [Clone ID: YR145]

CAT#: TA327618

Rabbit Monoclonal CD117/c-kit Antibody

Product Images

Immunohistochemistry staining of Paraffin GIST, tissue mast cells tissue by CD117/c-kit antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, membranous)

Specifications

Product Data

• Clone Name: YR145
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: KIT proto-oncogene receptor tyrosine kinase
• Database Link:
  NP_000213
  Entrez Gene 3815 Human
• Synonyms: C-Kit; CD117; PBT; SCFR
• Note: CD117, c-kit, is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium, and mast cells. This receptor is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma; however, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi’s sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Protein Kinase, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer