CD1 (CD1A) Rabbit Monoclonal Antibody [Clone ID: EP3622]

CAT#: TA327624

Rabbit Monoclonal CD1a Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil, thymus tissue by CD1a antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: EP3622
• Applications: IHC
• Recommended Dilution: IHC: 1:25 - 1:100
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD1a molecule
• Database Link:
  NP_001754
  Entrez Gene 909 Human
  UniProt ID P06126
• Synonyms: CD1; FCB6; HTA1; R4; T6
• Note: CD1a is a non-polymorphic major histocompatibitity complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with β-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a was reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage