CD23 (FCER2) Mouse Monoclonal Antibody [Clone ID: MRQ-57]

CAT#: TA327630

Mouse Monoclonal CD23 Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil, lymph node, chronic lymphocytic leukemia, small lymphocytic lymphoma tissue by CD23 antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: MRQ-57
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Formulation: The antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Fc fragment of IgE receptor II
• Database Link:
  NP_001993
  Entrez Gene 2208 Human
  UniProt ID P06734
• Synonyms: BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF
• Note: CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and B-cell Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL).

Reference Data

• Protein Families: Secreted Protein, Transmembrane
• Protein Pathways: Hematopoietic cell lineage