CD7 Mouse Monoclonal Antibody [Clone ID: MRQ-56]

CAT#: TA327651

Mouse Monoclonal CD7 Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil, Lymph node, Peripheral T-cell lymphoma tissue by CD7 antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: MRQ-56
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: The antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD7 molecule
• Database Link:
  NP_006128
  Entrez Gene 924 Human
  UniProt ID P09564
• Synonyms: GP40; LEU-9; Tp40; TP41
• Note: CD7 antigen is a cell surface glycoprotein of 40 kDa expressed on the surface of immature and mature T-cells as well as natural killer (NK) cells. It is a member of the immunoglobulin gene superfamily and is the first T-cell lineage associated antigen to appear in T-cell ontogeny, being expressed in T-cell precursors (preceding CD2 expression), and in myeloid precursors, in fetal liver and bone marrow, and persisting in circulating mature T-cells. While its precise function is not known, it is suggested that the molecule functions as an Fc receptor for IgM.CD7 is the most consistently expressed T-cell antigen in lymphoblastic lymphomas/leukemias, and therefore anti-CD7 is a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T-cell neoplasms, CD7 is the most common pan-T-antigen to be aberrantly expressed, which is a useful pointer to a neoplastic T-cell process.CD7 has been shown to be immunoexpressed in 85% of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, T-cell lymphoblastic leukemia/lymphoma, acute myeloid leukemia, and chronic myelogenous leukemia. CD7 is conspicuously absent in adult T-cell leukemia/lymphoma and is not expressed in mycosis fungoides.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage