Cytokeratin 5 (KRT5) Rabbit Monoclonal Antibody [Clone ID: EP1601Y]

CAT#: TA327666

Rabbit Monoclonal Cytokeratin 5 Antibody

Product Images

Immunohistochemistry staining of Paraffin Mesothelioma, prostate tissue by Cytokeratin 5 antibody (dilution: 1:50 - 1:200; visualization of staining: Cytoplasmic)

Specifications

Product Data

• Clone Name: EP1601Y
• Applications: IHC
• Recommended Dilution: IHC: 1:50 - 1:200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: keratin 5
• Database Link:
  NP_000415
  Entrez Gene 3852 Human
  UniProt ID P13647
• Synonyms: CK5; DDD; DDD1; EBS2; K5; KRT5A
• Note: Cytokeratin 5 is an intermediate filament protein of 58 kD molecular weight within the cytokeratin family. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Epithelioid mesotheliomas are strongly positive in all cases, but up to 11% of pulmonary adenocarinomas will show focal immunostaining. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with anti-CK 5. Anti-CK 5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-CK 5. This antibody, along with anti-CK 14, has found application in identifying basal-like breast carcinoma, a tumor with poor prognosis. Some carcinomas of ovarian origin may display anti-CK 5 positivity.