Desmin (DES) Mouse Monoclonal Antibody [Clone ID: D33]

CAT#: TA327670

Mouse Monoclonal Desmin Antibody

Product Images

Immunohistochemistry staining of Paraffin Muscle tissue by Desmin antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic)

Specifications

Product Data

• Clone Name: D33
• Applications: IHC
• Recommended Dilution: IHC: 1:25 - 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: desmin
• Database Link:
  NP_001918
  Entrez Gene 1674 Human
  UniProt ID P17661
• Synonyms: CSM1; CSM2; LGMD2R
• Note: Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. The light microscope has suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane-bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin (if they are of myogenic nature). This antibody is used to demonstrate the myogenic components/derivation of tumors.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)