E Cadherin (CDH1) Rabbit Monoclonal Antibody [Clone ID: EP700Y]

CAT#: TA327671

Rabbit Monoclonal e-cadherin Antibody

Product Images

Immunohistochemistry staining of Paraffin Breast tissue by e-cadherin antibody (dilution: 1:50 - 1:200; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: EP700Y
• Applications: IHC
• Recommended Dilution: IHC: 1:50 - 1:200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cadherin 1
• Database Link:
  NP_004351
  Entrez Gene 999 Human
  UniProt ID P12830
• Synonyms: Arc-1; CD324; CDHE; ECAD; LCAM; UVO
• Note: E-cadherin is an adhesion protein that is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, G.I. tract, and ovary. Another application involves the differentiation of ductal (which stains positive) vs. lobular cancer of the breast. It has also been shown to be positive in some thyroid carcinomas. Loss of E-cadherin expression has been suggested as a poor prognostic sign in breast carcinoma and non-small cell lung carcinoma.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer