S100P Mouse Monoclonal Antibody [Clone ID: 16/f5]

CAT#: TA327734

Mouse Monoclonal S100P Antibody

Product Images

Immunohistochemistry staining of paraffin Pancreatic ductal adenocarcinoma, urothelial carcinoma, placenta tissue by S100P antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, nuclear)

Specifications

Product Data

• Clone Name: 16/f5
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: S100 calcium binding protein P
• Database Link:
  NP_005971
  Entrez Gene 6286 Human
  UniProt ID P25815
• Synonyms: MIG9
• Note: S100P is a member of the S100 family of proteins. This family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. S100P was initially identified in the placenta at rather high levels. Anti-S100P with nuclear or nuclear/cytoplasmic immunoreactivity can be seen in essentially 100% of pancreatic ductal adenocarcinoma in pancreatic resection, and fine needle aspiration biopsy specimens. Anti-S100P displays no staining in the benign pancreatic ducts and acinar glands. S100P has been detected in the cells of virtually all intraductal papillary mucinous neoplasms tested. S100P is clearly expressed in the invasive component of intraductal papillary mucinous neoplasms (100%), including perineural, lymphatic, and minimal invasion. Biopsies of bile ducts with primary adenocarcinomas (90%) have exhibited strong nuclear and cytoplasmic staining for anti-S100P, with none of the 32 benign biopsies exhibiting anti-S100P immunoreactivity. An immunohistochemical panel including anti-S100P can be helpful in distinguishing adenocarcinoma from reactive epithelial changes on challenging bile duct biopsies. The detection of S100P expression can help distinguish urothelial carcinomas from other genitourinary neoplasms that enter into the differential diagnosis.