TTF1 (NKX2-1) Mouse Monoclonal Antibody [Clone ID: 8G7G3/1]

CAT#: TA327750

Mouse Monoclonal TTF-1 Antibody

Product Images

Immunohistochemistry staining of Paraffin Lung adenocarcinoma tissue by TTF-1 antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear)

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  Figure from citation: Immunohistochemistry of NKX2-1 (also known as TTF-1) protein level by using anti-NKX2-1 antibody in human biphasic pulmonary blastoma tissues, A-C: TTF-1, CK (AE1/AE3) and CK18 are positive in epithelial component (DAB. magnification ×200). View Citation

Specifications

Product Data

• Clone Name: 8G7G3/1
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NK2 homeobox 1
• Database Link:
  NP_003308
  Entrez Gene 7080 Human
  UniProt ID P43699
• Synonyms: BCH; BHC; EBP; NK-2; NKX2.1; NKX2A; NMTC1; T; TEBP; TITF1; TTF-1; TTF1
• Note: Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 labelling is also seen in thyroid malignancies.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors