ZAP70 Mouse Monoclonal Antibody [Clone ID: 2F3.2]
Other products for "ZAP70"
Specifications
Product Data | |
Clone Name | 2F3.2 |
Applications | IHC |
Recommended Dilution | IHC: 1:100 - 1:500 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Formulation | This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | zeta chain of T cell receptor associated protein kinase 70kDa |
Database Link | |
Synonyms | SRK; STCD; STD; TZK; ZAP-70 |
Note | ZAP-70 is a 70 kD protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP-70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP-70 negative) and Ig-unmutated (anti-ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP-70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis. |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway |
Documents
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.