c Kit (KIT) Rabbit Polyclonal Antibody

CAT#: TA327908

Rabbit Polyclonal Phospho-c-Kit (Tyr721) Antibody (Phospho-specific)

Product Images

Western blot analysis of c-Kit phosphorylation expression in HeLa whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human c-Kit around the phosphorylation site of Tyrosine 721.
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 120,145 kDa
• Gene Name: KIT proto-oncogene receptor tyrosine kinase
• Database Link:
  NP_001087241
  Entrez Gene 16590 MouseEntrez Gene 64030 RatEntrez Gene 3815 Human
  UniProt ID P10721
• Background: KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
• Synonyms: C-Kit; CD117; PBT; SCFR
• Note: Phospho-c-Kit (Tyr721) Antibody detects endogenous levels of c-Kit only when phosphorylated at Tyrosine 721.

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Protein Kinase, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer