PRDM1 Mouse Monoclonal Antibody [Clone ID: ROS195G]

CAT#: TA327929

Mouse Monoclonal anti-Blimp-1 Antibody

Product Images

A20 (lane 1) and PBMC (lane 2) cell extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-BLIMP - 1 antibody, ROS195G. Proteins were visualized using a HRP goat anti-mouse antibody and a chemiluminescence detection system

Specifications

Product Data

• Clone Name: ROS195G
• Applications: WB
• Recommended Dilution: WB, IHC, IP, IF, ELISA
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant GST-blimp-1 protein
• Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 98 Kd
• Gene Name: PR domain 1
• Database Link:
  NP_001189
  Entrez Gene 12142 MouseEntrez Gene 639 Human
  UniProt ID O75626
• Background: Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.
• Synonyms: BLIMP1; PRDI-BF1

Reference Data

• Protein Families: Transcription Factors