PARP1 Mouse Monoclonal Antibody [Clone ID: 5A5]

CAT#: TA327935

Mouse Monoclonal anti-PARP Antibody


USD 235.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 5A5
Applications IF, WB
Recommended Dilution IF, WB
Reactivities Human, Mouse
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Recombinant (partial), N-terminal 2/3 sequence of PARP
Formulation This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
Concentration lot specific
Purification The antibody was purified by affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 113 kD
Gene Name poly(ADP-ribose) polymerase 1
Background PARP (Poly (ADP-ribose) polymerase) is a 113 kD nuclear protein that can exist as a homo- or hetero-dimer. This protein acts as a molecular "nick sensor" and functions in base excision repair, poly(ADP-ribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2 and is a target for caspase cleavage during apoptosis. PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with PARP2, and interacts with PARP3. The 5A5 monoclonal antibody recognizes the N-terminal region of human and mouse PARP and has been shown to be useful for Western blotting and immunofluorescence staining.
Synonyms ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.