ATIC Mouse Monoclonal Antibody [Clone ID: F38P7H9]

CAT#: TA327986

Mouse Monoclonal anti-ATIC Antibody

Product Images

Western blot analysis of extract from Hela cells using anti-ATIC, clone F38P7H9.

Specifications

Product Data

• Clone Name: F38P7H9
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human, Mouse, Rat, Frog, and Fruit fly
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Ovalbumin-conjugated synthetic Peptide AHTNLRLFHH
• Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 65 kD
• Gene Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
• Database Link:
  NP_004035
  Entrez Gene 81643 RatEntrez Gene 108147 MouseEntrez Gene 471 Human
  UniProt ID P31939
• Background: ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, frog and fruit fly ATIC.
• Synonyms: AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: Metabolic pathways, One carbon pool by folate, Purine metabolism