CD46 Rat Monoclonal Antibody [Clone ID: TUG8]

CAT#: TA328055

Rat Monoclonal anti-mMCP-8 Antibody

Product Images

Cell extracts from untransfected NIH/3T3 cells (lane 1) or NIH/3T3 cells transfected with a plasmid encoding mMCP-8-Flag tagged protein (lane 2), using anti-mMCP-8, clone TUG8.

Specifications

Product Data

• Clone Name: TUG8
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant GST-mouse mMCP-8 fusion protein expressed in E.coli
• Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD46 molecule
• Database Link:
  NP_758860
  Entrez Gene 4179 Human
  UniProt ID P15529
• Background: mMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals.
• Synonyms: AHUS2; MCP; MIC10; TLX; TRA2.10

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades