BID Rat Monoclonal Antibody [Clone ID: 1H11]

CAT#: TA328058

Rat Monoclonal anti-BID Antibody

Product Images

Jurkat cell extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-BID antibody (clone 1H11). Proteins were visualized using a goat anti-rat IgG secondary conjugated to HRP and chemiluminescence detection.

Specifications

Product Data

• Clone Name: 1H11
• Applications: WB
• Recommended Dilution: WB, ELISA
• Reactivities: Human
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Bacteria expressed His tagged full length recombinant protein
• Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, 0.09% NaN₃.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kD
• Gene Name: BH3 interacting domain death agonist
• Database Link:
  NP_932071
  Entrez Gene 637 Human
  UniProt ID P55957
• Background: BID, a BH3 interacting domain death agonist is a member of the Bcl-2/Bcl-xL family. BID can form a heterodimer with either agonist BAX or antagonist Bcl-2. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8). After the cleavage by CASP8, the COOH-terminal part translocates to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
• Synonyms: FP497

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis