Rorc Hamster Monoclonal Antibody [Clone ID: RORg2]

CAT#: TA328099

Hamster Polyclonal anti-ROR gamma Antibody

Product Images

Mouse spleen (Lane 1), thymus (Lane 2) and thymus nuclear extract (Lane 3) cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with purified RORg2. Proteins were visualized using anti-hamster (Armenian) secondary antibody conjugated to HRP and a chemiluminescent system.

Specifications

Product Data

• Clone Name: RORg2
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Mouse ROR?
• Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RAR-related orphan receptor gamma
• Database Link:
  NP_035411
  Entrez Gene 19885 Mouse
  UniProt ID P51450
• Background: RORγ (Retinoid-related orphan receptor gamma) belongs to the nuclear hormone receptor family, NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. RORγ has two isoforms: γ1 and γ2 (also referred to as RORγt). The RORγt differs from the RORγ1 isoform in that it lacks the amino terminus of RORγ1. RORγ1 contains 516 amino acids and RORγt contains 495 amino acids. RORγ1 has a molecular weight of approximately 58 kD. RORγ1 is highly expressed in thymus, kidney, liver, muscle, and brown fat but not in white fat tissue. RORγt is specifically expressed in only two cell populations, DP thymocytes and lymphoid tissue inducers (LTi). RORγ plays a critical role in control apoptosis during thymopoiesis and T cell homeostasis. RORγt is to regulate TCRα repertoire by virtue of its positive regulatory role on Bcl-x expression. RORγ is essential for lymph nodes and Peyers patch development.
• Synonyms: MGC129539; NR1F3; RORG; RZR-GAMMA; RZRG; TOR