Phospholamban (PLN) Rabbit Polyclonal Antibody

CAT#: TA328116

Rabbit polyclonal anti-PLN antibody (N-term)

Product Images

Western blot analysis of lysate from U266 cell line, using PLN Antibody (N-term) (Cat. #TA328116).TA328116 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
• Formulation: PBS with 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phospholamban
• Database Link:
  NP_002658
  Entrez Gene 18821 MouseEntrez Gene 64672 RatEntrez Gene 5350 Human
  UniProt ID P26678
• Background: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
• Synonyms: CMD1P; CMH18; PLB

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Calcium signaling pathway, Dilated cardiomyopathy