DNA polymerase eta (POLH) Rabbit Polyclonal Antibody

CAT#: TA328145

Rabbit polyclonal anti-POLH antibody (N-term)

Product Images

POLH Antibody (N-term) (Cat.# TA328145) western blot analysis in CEM cell lysate (35ug/lane). This demonstrates that the POLH antibody detected the POLH protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This POLH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 68-92 amino acids from the N-terminal region of human POLH.
• Formulation: PBS with 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: polymerase (DNA) eta
• Database Link:
  NP_006493
  Entrez Gene 80905 MouseEntrez Gene 5429 Human
  UniProt ID Q9Y253
• Background: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.
• Synonyms: RAD30; RAD30A; XP-V; XPV

Reference Data

• Protein Families: Druggable Genome