TMC6 Rabbit Polyclonal Antibody

CAT#: TA328672

Rabbit Polyclonal Anti-TMC6 (EVER1)

Product Images

Western blot analysis of rat prostate (lanes 1and 4), rat testis (lanes 2 and 5) and rat placenta (lanes 3 and 6): 1-3. Anti-TMC6 (EVER1) antibody, (1:800). 4-6. Anti-TMC6 (EVER1) antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide CGPFRTLDTMYEAGR, corresponding to amino acid residues 681-695 of human TMC6. Intracellular, Cytoplasm.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transmembrane channel like 6
• Database Link:
  NP_009198
  Entrez Gene 688280 RatEntrez Gene 11322 Human
  UniProt ID Q7Z403
• Background: EVER gene belongs to larger family of proteins referred to as the transmembrane channel-like protein (TMC) family. EVER1/TMC6 protein, integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1) a membrane protein responsible for zinc efflux and resistance to zinc toxicity, thereby controlling the cellular zinc balance. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs. The EVER1 gene encodes 2 alternatively spliced proteins, one of 805 amino acids and the other of 454 amino acids, in the same open reading frame. The EVER genes are thought to be transcribed in numerous tissues including the skin. Mutations in the TMC6 are implicated in the development of the rare autosomal recessive disease Epidermodysplasia Verruciformis (EV). EV is characterized by extreme susceptibility to infection by cutaneous human papillomaviruses (HPV) of the beta genus. The TMC6 genes may be involved in controlling HPV gene expression and replication in epidermal keratinocytes or they may directly affect innate and adaptive immune responses which control the clearance of HPV-infected keratinocytes in EV cases. A recent report indicated an association between genetic variation in the TMC6 region and development of cervical cancer (CxCa) .
• Synonyms: EV1; EVER1; EVIN1; LAK-4P

Reference Data

• Protein Families: Transmembrane