p75 NGF Receptor (NGFR) Rabbit Polyclonal Antibody

CAT#: TA328684

Rabbit Polyclonal Anti-Neurotensin Receptor 2


USD 585.00

2 Weeks*

Size
    • 200 ul

Other products for "NGFR"

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide CGEQHSLVPLPQEAPE, corresponding to amino acidresidues 377-392 of rat Neurotensin Receptor 2. Intracellular, C-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name nerve growth factor receptor
Background Neurotensin receptor 2 (NTS2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract. NTS2 and NTS1 belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily while the third neurotensin receptor NTS3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTS1 and NTS3 bind neurotensin with high affinity while NTS2 binds it with low affinity. NTS2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+ mobilization. However, the exact signaling mechanisms subsequent to NTS2 activation appear to depend on the species and on the cellular system in which the receptor is studied. NTS2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion. The most established physiological role of NTS2 is its role in pain transmission as NTS2-defficient mice showed that NTS2 is the likely mediator of the neurotensin-induced analgesic responses.
Synonyms CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Neurotrophin signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.