Cacna1b Rabbit Polyclonal Antibody

CAT#: TA328722

Rabbit Polyclonal Anti-CaV2.2


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)RHHRHRDRDKTSASTPA, corresponding to amino acid residues 851-867 of rat Cav2.2. Intracellular loop between domains II and III.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name calcium voltage-gated channel subunit alpha1 B
Background Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; a1, Ã?, a2d and ?. CaV channels were originally divided into six physiological types: L, N, P, Q, R, and T type.The CaV2.2 (formally named a1B) composes the a1 poreforming subunit for the N type Ca2+ channel family. They are involved in neurotransmitter release from central neurons, including glutamate, ?-aminobutyric acid, acetylcholine, dopamine and noradrenaline.The CaV2.2 is expressed preferentially in the central nervous system, where along with CaV2.1, it is responsible for pre-synaptic Ca2+ influx and neurotransmitter release.The CaV2.2 channel is negatively regulated by many different GPCRs. There are two ways that this is done: either by directly binding GÃ?? to the channel or by an indirect mechanism involving second messenger and channel phosphorylation.?-Conotoxin GVIA is a specific blocker of Cav2.2 Ca2+ channels. It specifically blocks N-type Cav channels by binding to the Cav2.2 a1 subunit (a1B) and its action is only partially reversible.
Synonyms BIII; CACH5; CACNL1A5; CACNN; Cav2.2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.