Cacna1c Rabbit Polyclonal Antibody

CAT#: TA328723

Rabbit Polyclonal Anti-CaV1.2

Product Images

Western blot analysis of rat brain membranes: 1. Anti-CaV1.2 antibody, (1:200). 2. Anti-CaV1.2 antibody, preincubated with the control peptide antigen.

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  Expression of Cav1.2 in mouse cerebellum. Immunohistochemical staining of mouse cerebellum with Anti-Cav1.2 antibody. A. Cav1.2 (red) appears in Purkinje cells (horizontal arrows) and is distributed diffusely in the molecular layer (Mol) including in Purkinje dendrites (vertical arrows). B. Staining of Purkinje nerve cells with mouse anti-Calbindin 28K (green) demonstrates the location of dendrites in the molecular layer. C. Merged image of panels A and B.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat Cav1.2. Intracellular loop between domains II and III.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium voltage-gated channel subunit alpha1 C
• Database Link:
  NP_036649
  Entrez Gene 775 HumanEntrez Gene 12288 MouseEntrez Gene 24239 Rat
  UniProt ID P22002
• Background: All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dIHCydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine, Calciseptine and FS-2 .
• Synonyms: CACH2; CACN2; CACNL1A1; CaV1.2; CCHL1A1; MGC120730; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196739; OTTHUMP00000196744; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196751; TS