Cacna1g Rabbit Polyclonal Antibody

CAT#: TA328736

Rabbit Polyclonal Anti-CaV3.1

Product Images

Western blot analysis of rat brain membranes: 1. Anti-Cav3.1 antibody, (1:200). 2. Anti-Cav3.1 antibody, preincubated with the control peptide antigen.

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  Expression of CaV3.1 in rat cerebellum. Immunohistochemical staining of rat cerebellum using Anti-CaV3.1 antibody. A. CaV3.1 immunoreactivity (green) appears in the molecular layer. B. Nuclear staining using DAPI as the counterstain (blue). C. Merged images A and B. Mol = molecular layer.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide MDEEEDGAGAEESGQPRSFTQL(C), corresponding to amino acid residues 1-22 of rat CaV3.1 (Accession O54898). Intracellular, N-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium voltage-gated channel subunit alpha1 G
• Database Link:
  NP_113789
  Entrez Gene 8913 HumanEntrez Gene 12291 MouseEntrez Gene 29717 Rat
• Background: Voltage-dependent Ca2+ channels provide a pathway for rapid influx of Ca2+ into cells, which plays a crucial role in both electrical and metabolic signaling. T-type currents are transduced via channel proteins encoded by three genes that compose a subfamily within the Cav channel family. The activity of T-type channels contributes to several known physiological and pathophysiological phenomena including burst firing in neurons, pace making activity in the heart and secretion from endocrine tissues. There are three cloned T-type channel isoforms.CaV3.1 (a1G) and CaV3.2 (a1H) are widely distributed whereas the expression of CaV3.3 (a1I) is restricted to the central nervous system. CaV3.1 and CaV3.2 are also expressed in the kidney, but little is known about their physiological role there.
• Synonyms: Ca(V)T.1; Cav3.1; MGC117234; NBR13