Cacnb2 Rabbit Polyclonal Antibody

CAT#: TA328763

Rabbit Polyclonal Anti-CaVBeta2

Product Images

Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) membranes: 1, 2. Anti-CaVβ2 antibody, (1:800). 3, 4. Anti-CaVβ2 antibody preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)HEHVDRYVPHREHNHRE, corresponding to amino acid residues 571-587 of rat CavÃ?2. Intracellular, C-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium voltage-gated channel auxiliary subunit beta 2
• Database Link:
  NP_446303
  Entrez Gene 12296 MouseEntrez Gene 116600 Rat
  UniProt ID Q8VGC3
• Background: Voltage-dependent Ca2+ channels are a family of membrane proteins that allow cells to couple electrical activity to intracellular Ca2+ signaling. Voltage-gated Ca2+ channels are classified as T, L, N, P, Q and R, and are distinguished by their sensitivity to pharmacological blocks, single-channel conductance kinetics, and voltage-dependence.On the basis of their voltage activation properties, voltage-gated Ca2+ subtypes can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels. The activity of the channel pore is modulated by 4 tightly-coupled subunits: an intracellular Ã? subunit; a transmembrane ? subunit; and a disulphide-linked complex of a2 and d subunits. There are four distinct Ã? subunits: Ã?1, Ã?2, Ã?3 and Ã?4. There are 4 splice variants of the Ã?2 subunit: Ã?2a, Ã?2b, Ã?2c and Ã?2d. Ã?2a and Ã?2b are expressed in heart, aorta and brain, and are 606- and 632-residue proteins, respectively. Ã?2c and Ã?2d (655 and 604 residues, respectively) are expressed in brain, and recent studies show beta-2c to be also expressed in heart. All splice variants differ in their N-terminal regions.
• Synonyms: CAB2; CACNLB2; CAVB2; FLJ23743; MYSB