Cacng4 Rabbit Polyclonal Antibody

CAT#: TA328766

Rabbit Polyclonal Anti-CaVGamma4

Product Images

Western blot analysis of rat brain (lanes 1 and 5), mouse brain (lanes 2 and 6), SH-SY5Y (lanes 3 and 7) and PC-12 (lanes 4 and 8) lysates: 1-4. Anti-Cav?4 antibody. 5-8. Anti-Cav?4 antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)EKNKELRFKTKRE, corresponding to amino acid residues 208-220 of rat Cav?4. Intracellular, C-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium voltage-gated channel auxiliary subunit gamma 4
• Database Link:
  NP_542423
  Entrez Gene 27092 HumanEntrez Gene 54377 MouseEntrez Gene 140725 Rat
  UniProt ID Q8VHW9
• Background: Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction migration and excitation.They are composed of several subunits; a1, Ã?, a2d and ?. CaV channels were originally divided into six physiological types: L, N, P, Q, R, and T type.L-type calcium channels are composed of five subunits. Cav?4, represents one of these subunits, and is one of several ? subunit proteins. It is an integral membrane protein that is thought to stabilize the Ca2+ channel in an inactive (closed) state. The encoding gene is a member of the neuronal Ca2+ channel ? subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.Cav?4, along with Cav?2, Cav?3 and Cav?8 have been associated with AMPA receptors and have been shown to modulate the trafficking of receptors to the plasma membrane as well as electrophysiological key properties.
• Synonyms: MGC11138; MGC24983