Clic5 Rabbit Polyclonal Antibody

CAT#: TA328786

Rabbit Polyclonal Anti-CLIC5


USD 585.00

3 Weeks*

Size
    • 200 ul

Product Images

Other products for "Clic5"

Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:200-1:2000
Reactivities Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)DTNTHGDEKGSQRK, corresponding to amino acid residues 161- 174 of rat CLIC5. Intracellular, C-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name chloride intracellular channel 5
Background Chloride (Cl) channels are membrane, anion-selective protein pores, which diffusively transport negative ions across their electrochemical gradient. Cl channels are subdivided into six unique families, and their regulation mechanisms range from voltage-dependency, through G-protein activation, to mechanosensitivity; they may reside in either the plasma membrane or the membrane of intracellular compartments or both. They are detected in the kidney, placenta, intestines, brain and the inner-ear. The vertebrate Cl intracellular channel (CLIC) family is composed of 6 highly conserved members (CLIC1-6); each exists as a ~250 residue protein which can assume both a soluble fold and a membrane-integral form. The latter consists of a single trans-membrane domain and is subsequently oligomerized to construct a functioning channel. Interestingly, channels composed of CLIC4 and CLIC5 have been confirmed to be equally permeable to K+ and Cl. CLIC5, to which there are two isoforms - CLIC5A and CLIC5B - encoded by the same gene, has first been isolated from human placenta, and was shown, together with CLIC4 (with which it shares 76% homology), to be enriched in the apical microvilli-containing part of the trophoblast epithelium, where, unlike CLIC4, it interacts with the actin cytoskeleton. CLIC5 shares about 40% homology with CLIC1-4 and is distributed to a high degree in myocytes, cardiomyocytes and stereocillia of the inner-ear. Mice mutated in the Clic5 gene lack coordination and gradually become deaf, show resistance to obesity, experience gastric ulcers and the resultant hemorrhage, and have higher incidence of entering torpor.
Synonyms CLIC5B; dJ447E21.4; FLJ90663; MST130; MSTP130
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.