Gabra4 Rabbit Polyclonal Antibody

CAT#: TA328815

Rabbit Polyclonal Anti-GABA(A) alpha4 (extracellular)


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide NSKDEKLSPENFTR(C), corresponding to amino acid residues 37-50 of rat GABA(A) a4 with replacement of C44 with serine. Extracellular, N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name gamma-aminobutyric acid type A receptor alpha4 subunit
Background GABA (?-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.The GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.GABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: a, Ã?, ?, d, e, p, ?, and ?. Six a subunit isoforms have been found to exist in mammals (a1-a6). In most cases, native GABAA receptors consist of 2a, 2Ã?, and 1? subunits. The a subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.Each subtype has a unique regional expression in the brain, and individual neurons often express multiple subtypes. For example, the a4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain.
Synonyms GABRA4
Note This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.