Chrna6 Rabbit Polyclonal Antibody

CAT#: TA328884

Rabbit Polyclonal Anti-Nicotinic Acetylcholine Receptor Alpha6 (extracellular)


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)EQLFHTLFAHYNR, corresponding to amino acid residues 35-47 of rat nAChRa6. Extracellular, N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name cholinergic receptor nicotinic alpha 6 subunit
Background Neuronal nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of ligand-gated ion channels and are widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling.Nicotinic acetylcholine receptors containing a6 subunits (nAChRa6) exhibit a unique expression pattern in the mammalian brain. nAChRs a6 are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. nAChRa6 expressed on DAergic neurons can be activated by endogenous acetylcholine (Ach) or exogenous nicotine and analogs, which suggests that the activation of nAChRa6 may play a vital role in central cholinergic circuits, including modulation of locomotor behaviour and drug addiction. In addition, nAChRa6 is particularly susceptible to nigrostriatal damage, which may lead to Parkinsonâ??s disease (PD). nAChRa6 are also expressed by sensory neurons; therefore, they may also play a role in disorders related to sensory perception.
Synonyms CHNRA6
Note This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.