Nlgn1 Rabbit Polyclonal Antibody

CAT#: TA328901

Rabbit polyclonal Anti-Neuroligin 1 (extracellular)


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)KVPSTDITLRPTRK, corresponding to amino acid residues 648-661 of rat Neuroligin 1 (). Extracellular, N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name neuroligin 1
Background The NLGN1 gene encodes a member of a family of neuronal cell surface proteins. Neuroligins act as ligands for Ã?-Neurexins, cell adhesion proteins located presynaptically. Neuroligin and Ã?-neurexin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neuroligin 1 may be involved in the formation and remodeling of central nervous system synapses.Proteins of this family may also mediate signaling by recruiting and stabilizing key synaptic components. This is done by interacting with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures.Mutations in the Neuroligin genes are implicated in autism and other cognitive disorders.Neuroligins have been found to play a role in angiogenesis, specifically in human pheripheral tissues.Neuroligins bind with the help of Ca2+ to the a-neurexin LNS (laminin, neurexin and sex hormone-binding globulin-like folding units) domains and to the Ã?-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code4. This binding results in a heterotetramer made up of a Neuroligin-1 dimer and two Neurexin-1 Ã? monomers.
Synonyms KIAA1070; MGC45115; NL1; OTTHUMP00000211275; OTTHUMP00000211276
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.