Kcnj4 Rabbit Polyclonal Antibody

CAT#: TA328941

Rabbit polyclonal Anti-Kir2.3

Product Images

Western blot analysis of rat kidney (1, 3) and rat brain (2, 4) membranes: 1, 2. Anti-Kir2.3 antibody, (1:200) 3, 4. Anti-Kir2.3, antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)EFGS HLDLE RMQAA TLPLD N, corresponding to amino acid residues 418-437 of rat Kir2.3.Intracellular, C-terminal part.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium voltage-gated channel subfamily J member 4
• Database Link:
  NP_446322
  Entrez Gene 16520 MouseEntrez Gene 116649 Rat
  UniProt ID P52190
• Background: Kir2.3 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.The familyâ??s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers.Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.Kir2.3 is a member of the Kir2.x subfamily that includes four members (Kir2.1- Kir2.4) that are characterized by strong inward rectification and high constitutive activity.Kir2.3 is expressed in a variety of tissues including heart and brain. In the heart, Kir2.3 forms heteromers with Kir2.1 and underlay the IK1 current (at least in some species) that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.
• Synonyms: HIR; HIRK2; HRK1; IRK3; Kir2.3; MGC142066; MGC142068