Kcnn4 Rabbit Polyclonal Antibody

CAT#: TA328961

Rabbit polyclonal Anti-KCa3.1 (SK4, IKCa1)

Product Images

Western blot analysis of HEK-293-KCa3.1 (1, 2) and K562 (3, 4) cells: 1, 3. Anti-KCa3.1 (SK4, IKCa1) antibody, (1:200). 2, 4. Anti-KCa3.1 (SK4, IKCa1) antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide RQVRLKHRKLREQV(C), corresponding to amino acid residues 350-363 of rat KCa3.1. Intracellular, C-terminal part.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily N member 4
• Database Link:
  NP_075410
  Entrez Gene 3783 HumanEntrez Gene 16534 MouseEntrez Gene 65206 Rat
• Background: KCa3.1 is part of the Ca2+ activated K+ channels family that share the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is six transmembrane domains and intracellular N- and C-termini. KCa3.1 is widely expressed in epithelial, endothelial and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel. The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCa3.1 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCa3.1 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.
• Synonyms: hIKCa1; hKCa4; hSK4; IK1; IKCA1; KCa3.1; KCA4; SK4