Kcnc3 Rabbit Polyclonal Antibody

CAT#: TA328965

Rabbit polyclonal Anti-KV3.3

Product Images

Western blotting of rat brain membranes: 1. Anti-Kv3.3 antibody (1:200). 2. Anti-Kv3.3 antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide KSPITPGSRGRYSRDRAC, corresponding to? amino acid residues 701-718 of rat Kv3.3 . Intracellular, C-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium voltage-gated channel subfamily C member 3
• Database Link:
  NP_446449
  Entrez Gene 3748 HumanEntrez Gene 16504 MouseEntrez Gene 117101 Rat
• Background: Kv3.3 is a member of the Shaw type family of voltage-gated K+ channels that includes four members (Kv3.1-3.4). Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.3 is mostly localized in the brain, although it has been observed in vascular smooth muscle cells and eye epithelium. In the brain its expression pattern largely overlaps that of the Kv3.1 channel suggesting that they may form functional heteromers. Indeed, mouse knockouts of both Kv3.1 and Kv3.3, but not either channel alone, display severe motor defects.
• Synonyms: KSHIIID; KV3.3; SCA13