Kcnab1 Rabbit Polyclonal Antibody

CAT#: TA328980

Rabbit polyclonal Anti-KVBeta1


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:200-1:2000
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)TPQHHISLKESTAK, corresponding to amino acid residues 54-67 of rat KVÃ?1. N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name potassium voltage-gated channel subfamily A member regulatory beta subunit 1
Background Voltage-gated K+ channels represent a structurally and functionally diverse group of membrane proteins. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle1. The duration of the open states of K+ channels is determined by the rates of deactivation and inactivation. KV channels are hetero-oligomeric complexes consisting of two different types of subunits: membrane-bound, pore-forming a subunits and the smaller Ã? subunits. The Ã? subunits appear to be peripheral proteins tightly associated with the cytoplasmic side of the a subunits. The inactivation gate can be formed by an N-terminal segment of an auxiliary Ã?-subunit, as in the complex of KVÃ?1 and KVa family channels3. There are three mammalian KVÃ? genes: KVÃ?1, KVÃ?2 and KVÃ?3. Additional variability in the KVÃ?1 family results from alternative splicing in the amino terminal region, thus yielding the KVÃ?1.1, KVÃ?1.2, and KVÃ?1.3 subunits.
Synonyms AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.