P2rx7 Rabbit Polyclonal Antibody

CAT#: TA328994

Rabbit polyclonal Anti-P2X7 Receptor

Product Images

Western blot analysis of rat hippocampus lysates: 1. Anti-P2X7 Receptor antibody, (1:200). 2. Anti-P2X7 Receptor antibody, preincubated with the control peptide antigen.

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  Expression of P2X7 Receptor in rat pancreas. Immunohistochemical staining of rat paraffin-embedded endocrine and exocrine pancreas sections using Anti-P2X7 Receptor antibody, (1:50), followed by goat anti-rabbit-AlexaFluor-555-secondary antibody (1:500), (red). Staining is highly specific for endocrine cells of the Isle of Langerhans. Hoechst 33342 is used as the counterstain (blue).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 Receptor?. Intracellular, C-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: purinergic receptor P2X 7
• Database Link:
  NP_062129
  Entrez Gene 5027 HumanEntrez Gene 18439 MouseEntrez Gene 29665 Rat
  UniProt ID Q64663
• Background: The P2X7 receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family is composed of seven receptor subtypes, named P2X1-P2X7, all of which have been cloned. The various P2X receptors show distinct expression patterns. P2X1-6 receptors have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly in antigen-presenting cells, and microglia. The P2X7 receptor mediates the release of proinflamatory cytokines and stimulation of transcription factors and may also play an important role in apoptosis.
• Synonyms: MGC20089; P2X7