Scn1b Rabbit Polyclonal Antibody

CAT#: TA329046

Rabbit polyclonal Anti-NaVBeta1 (extracellular)


USD 585.00

3 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivities Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide CKRRSETTAETFTE, corresponding to amino acid residues 43-56 of rat NavÃ?1 . Extracellular, N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name sodium voltage-gated channel beta subunit 1
Background Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability. To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.2,3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β-subunits (Nav β-subunit). The Nav β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems. Navβ-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane signaling, and cell adhesion molecules. In the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit. This association appears to be a late event in sodium channel biosynthesis.
Synonyms GEFSP1
Note This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.