MADH7 (SMAD7) Rabbit Polyclonal Antibody

CAT#: TA329746

Rabbit Polyclonal Anti-SMAD7 Antibody

Product Images

WB Suggested Antibody Titration: 0.2-1 ug/ml; Positive Control: Lung

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  WB Suggested Anti-SMAD7 Antibody ; Positive Control: Lane 1: 2ug Flag-SMAD7 transfected 293 extracts; Primary Antibody Dilution : 1:500; Secondary Antibody : Goat anti-rabbit-HRP; Secondry Antibody Dilution : 1:5000; Submitted by: Anonymous

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-SMAD7 antibody: synthetic peptide directed towards the N terminal of human SMAD7. Synthetic peptide located within the following region: EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46 kDa
• Gene Name: SMAD family member 7
• Database Link:
  NP_005895
  Entrez Gene 4092 Human
  UniProt ID O15105
• Background: Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
• Synonyms: CRCS3; MADH7; MADH8
• Note: Immunogen sequence homology: Human: 100%; Dog: 93%; Pig: 93%; Bovine: 93%; Rabbit: 93%; Mouse: 92%; Rat: 85%

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: TGF-beta signaling pathway