TIP49A (RUVBL1) Rabbit Polyclonal Antibody

CAT#: TA330264

Rabbit Polyclonal Anti-RUVBL1 Antibody

Product Images

WB Suggested Anti-RUVBL1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human heart

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  Host: Rabbit; Target Name: RUVBL1; Sample Tissue: Human Fetal Lung; Antibody Dilution: 1.0ug/ml

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  WB Suggested Anti-RUVBL1 Antibody ; Positive Control: Lane 1: 30ug K562 lysate; Primary Antibody Dilution : 1:200; Secondary Antibody : Anti-rabbit-HRP; Secondry Antibody Dilution : 1:1000; Submitted by: Sustackova Gabriela

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-RUVBL1 antibody: synthetic peptide directed towards the N terminal of human RUVBL1. Synthetic peptide located within the following region: KIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGV
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 50 kDa
• Gene Name: RuvB like AAA ATPase 1
• Database Link:
  NP_003698
  Entrez Gene 8607 Human
  UniProt ID Q9Y265
• Background: RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
• Synonyms: ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A
• Note: Immunogen sequence homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Zebrafish: 100%; Guinea pig: 100%; Goat: 77%

Reference Data

• Protein Families: Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Wnt signaling pathway